Lauren Bishop, an efficient executive, meets Clay Harding, the son of the owner of the company where she works, in a business meeting. After having intense sexual intercourse, they decide to deviate the company money to a Swiss bank. Last, a cheating game between them two will make a winner and a looser.

There exists an ancient manuscript still writing itself called the Lexicon. It supposedly tells of the coming of the Anti-Christ, and happens to fall into the hands of an unsuspecting woman. Now, she is being pursued by angels intent on obtaining the information from the book.

In Bucharest, Allison is protecting the mysterious bible, "The Prophet Lexicon", where the last chapter about the apocalypse, called Revelations, discloses the name of the Antichrist in its last page. Meanwhile, the evil and jealous leader of the renegade angels Thrones, Stark, forces the hit-man Dylan to kill Allison to get the information about the Antichrist, but Dylan mysteriously feels attracted by the woman, protecting her against the Thrones. Allison seeks John Reigart for help, but Satan tell her that he is interested in the apocalypse to gather millions of souls to Hell. Alone and betrayed, Allison discloses the truth about her origins, while protecting the Lexicon.

Will, an escaped convict, inadvertently takes refuge in a barn the same night the owners, April and Martin, get into a terrible fight. A gun shot goes off inside the house. April drags Martin's body outside and discovers Will. He convinces her that he is not there to harm her but has witnessed the murder so they must cooperate or both go to prison. The two take out to dispose of the body only to find out he is not dead. The task of disposal turns into a kidnapping nightmare and, as the two try to navigate the turn of events, they find they must make some hard choices to keep from losing it all.

When a documentary crew traveling through the Amazon jungle, picks up a stranded man, they are unaware of the trouble that will occur. This stranger's hobby is to capture the giant Anaconda snake, and plans to continue targeting it on their boat, by any means necessary.